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Information for Researchers

the intersection of Infectious disease and cancer Research

The National Centre for Infections in Cancer is a network of researchers who aim to improve cancer patient morbidity and mortality associated with infectious diseases.

 

Resources

We are currently running several studies on infections in cancer. Click to find out more 

News worthy stories and papers

 

Investigator presentations (password required)

 

NCIC Publications

(April 2018)

Management of fever and neutropenia in children with cancer: A survey of Australian and New Zealand practice.

Haeusler GM, Slavin MA, Bryant PA, Babl FE, Mechinaud F, Thursky KA.

J Paediatr Child Health. 2018 Apr 14. doi: 10.1111/jpc.13899

(March 2018)

Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.

Sim SA, Leung VKY, Ritchie D, Slavin MA, Sullivan SG, Teh BW.

Biol Blood Marrow Transplant. doi: 10.1016/j.bbmt.2018.03.004

Factors contributing to declination of annual influenza vaccination by healthcare workers caring for cancer patients: An Australian experience.

Surtees TC, Teh BW, Slavin MA, Worth LJ.

Vaccine. doi: 10.1016/j.vaccine.2018.02.098

(Jan 2018)

In vitro activity of the novel antifungal compound F901318 against Australian Scedosporium and Lomentospora fungi.

Biswas C, Law D, Birch M, Halliday C, Sorrell TC, Rex J, Slavin M, Chen SC.

Med Mycol. doi: 10.1093/mmy/myx161

Pharmacokinetics and safety results from the phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease

Cornely O, Robertson M, Haider S, Grigg AP, et al.

J Antimicrob Chemother (in press), 2017

Limited utility of routine chest X-ray in initial evaluation of neutropenic fever (NF) in patients with haematological diseases undergoing chemotherapy

Estacio O, Loh Z, Baker A, Chong G, Grigg AP, Churilov L, Hawkes EA.

Int Med J:  DOI: 10.1111/imj.13712, 2018

ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients.

Cesaro S, Dalianis T, Hanssen Rinaldo C, Koskenvuo M, Pegoraro A, Einsele H, Cordonnier C, Hirsch HH; ECIL-6 Group.

J Antimicrob Chemother. 2018 Jan 1;73(1):12-21.doi: 10.1093/jac/dkx324.

Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines.

Mikulska M, Averbuch D, Tissot F, Cordonnier C, Akova M, Calandra T, Ceppi M, Bruzzi P, Viscoli C; European Conference on Infections in Leukemia (ECIL).

J Infect. 2018 Jan;76(1):20-37. doi: 10.1016/j.jinf.2017.10.009

(Dec 2017)

Single-centre study of therapeutic drug monitoring of posaconazole in lung transplant recipients: factors affecting trough plasma concentrations.

Jeong W, Snell GI, Levvey BJ, Westall GP, Morrissey CO, Wolfe R, Ivulich S, Neoh CF, Slavin MA, Kong DCM.

J Antimicrob Chemother. 2017 Dec 2. doi: 10.1093/jac/dkx440

What, where and why: exploring fluorodeoxyglucose-PET's ability to localise and differentiate infection from cancer.

Douglas A, Lau E, Thursky K, Slavin M.

Curr Opin Infect Dis. 2017 Dec;30(6):552-564. doi: 10.1097/QCO.0000000000000405.

Impact of a dedicated post-transplant vaccination service at an Australian cancer centre.

Teh BW, Joyce T, Slavin MA, Thursky KA, Worth LJ.

Bone Marrow Transplant. 2017 Dec;52(12):1681-1683. doi: 10.1038/bmt.2017.195

Cart before the horse: use of Aspergillus PCR to increase the diagnostic yield from BAL in hematological patients at risk of invasive aspergillosis.

Smibert OC, Slavin MA.

Leuk Lymphoma. 2017 Dec;58(12):2773-2776. doi: 10.1080/10428194.2017.1330479.

(Nov 2017)

The 3 Cs of Antibiotic Allergy-Classification, Cross-Reactivity, and Collaboration.

Trubiano JA, Stone CA, Grayson ML, Urbancic K, Slavin MA, Thursky KA, Phillips EJ.

J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1532-1542. doi: 10.1016/j.jaip.2017.06.017

Low T-Cell Responses to Mitogen Stimulation Predicts Poor Survival in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.

Yong MK, Cameron PU, Slavin MA, Cheng AC, Morrissey CO, Bergin K, Spencer A, Ritchie D, Lewin SR.

Front Immunol. 2017 Nov 9;8:1506. doi: 10.3389/fimmu.2017.01506

Cytomegalovirus Reactivation Is Associated with Increased Risk of Late-Onset Invasive Fungal Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Study in the Current Era of Viral Load Monitoring.

Yong MK, Ananda-Rajah M, Cameron PU, Morrissey CO, Spencer A, Ritchie D, Cheng AC, Lewin SR, Slavin M.

Biol Blood Marrow Transplant. 2017 Nov;23(11):1961-1967. doi: 10.1016/j.bbmt.2017.07.025

Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer.

Colombo AL, de Almeida Júnior JN, Slavin MA, Chen SC, Sorrell TC.

Lancet Infect Dis. 2017 Nov;17(11):e344-e356. doi: 10.1016/S1473-3099(17)30304-3.

Critical review of current clinical practice guidelines for antifungal therapy in paediatric haematology and oncology.

Blyth CC, Haeusler GM, McMullan BJ, Kotecha RS, Slavin MA, Clark JE.

Support Care Cancer. 2017 Nov;25(11):3289-3290. doi: 10.1007/s00520-017-3681-0.

(Oct 2017)

The Combined Utility of Ex vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In vivo Skin Testing in Patients With Antibiotic-Associated Severe Cutaneous Adverse Reactions.

Trubiano JA, Strautins K, Redwood AJ, Pavlos R, Konvinse KC, Aung AK, Slavin MA, Thursky KA, Grayson ML, Phillips EJ.

J Allergy Clin Immunol Pract. 2017 Oct 31. pii: S2213-2198(17)30728-6. doi: 10.1016/j.jaip.2017.09.004

Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling.

Teh BW, Harrison SJ, Allison CC, Slavin MA, Spelman T, Worth LJ, Thursky KA, Ritchie D, Pellegrini M.

Front Immunol. 2017 Oct 5;8:1247. doi: 10.3389/fimmu.2017.01247

Safety and cost benefit of an ambulatory program for patients with low-risk neutropenic fever at an Australian centre.

Teh BW, Brown C, Joyce T, Worth LJ, Slavin MA, Thursky KA.

Support Care Cancer. 2017 Oct 10. doi: 10.1007/s00520-017-3921-3

Ibrutinib may impair serological responses to influenza vaccination.

Douglas AP, Trubiano JA, Barr I, Leung V, Slavin MA, Tam CS.

Haematologica. 2017 Oct;102(10):e397-e399. doi: 10.3324/haematol.2017.164285

Incidence, etiology and timing of infections following azacitidine therapy for myelodysplastic syndromes.

Trubiano JA, Dickinson M, Thursky KA, Spelman T, Seymour JF, Slavin MA, Worth LJ.

Leuk Lymphoma. 2017 Oct;58(10):2379-2386. doi: 10.1080/10428194.2017.1295141.

Is a biomarker-based diagnostic strategy for invasive aspergillosis cost effective in high-risk haematology patients?

Macesic N, Morrissey CO, Liew D, Bohensky MA, Chen SC, Gilroy NM, Milliken ST, Szer J, Slavin MA.

Med Mycol. 2017 Oct 1;55(7):705-712. doi: 10.1093/mmy/myw141.

(Sept 2017)

External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules.

Haeusler GM, Thursky KA, Slavin MA, Mechinaud F, Babl FE, Bryant P, De Abreu Lourenco R, Phillips R.

Pediatr Infect Dis J. 2017 Sep 5. doi: 10.1097/INF.0000000000001777

Identification of genetic markers of resistance to echinocandins, azoles and 5-fluorocytosine in Candida glabrata by next-generation sequencing: a feasibility study.

Biswas C, Chen SC, Halliday C, Kennedy K, Playford EG, Marriott DJ, Slavin MA, Sorrell TC, Sintchenko V.

Clin Microbiol Infect. 2017 Sep;23(9):676.e7-676.e10. doi: 10.1016/j.cmi.2017.03.014.

(July 2017)

Predicting Infectious ComplicatioNs in Children with Cancer: an external validation study.

Haeusler GM, Thursky KA, Mechinaud F, Babl FE, De Abreu Lourenco R, Slavin MA, Phillips R.

Br J Cancer. 2017 Jul 11;117(2):171-178. doi: 10.1038/bjc.2017.154

Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation.

Trubiano JA, Thursky KA, Stewardson AJ, Urbancic K, Worth LJ, Jackson C, Stevenson W, Sutherland M, Slavin MA, Grayson ML, Phillips EJ.

Clin Infect Dis. 2017 Jul 1;65(1):166-174. doi: 10.1093/cid/cix244.

Clinical effectiveness of early posaconazole suspension pre-emptive therapy in lung transplant recipients: The Alfred's experience.

Jeong W, Snell GI, Levvey BJ, Westall GP, Morrissey CO, Ivulich S, Neoh CF, Slavin MA, Kong DCM.

J Antimicrob Chemother. 2017 Jul 1;72(7):2089-2092. doi: 10.1093/jac/dkx085.

(June 2017)

Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation.

Yong MK, Cameron PU, Slavin M, Morrissey CO, Bergin K, Spencer A, Ritchie D, Cheng AC, Samri A, Carcelain G, Autran B, Lewin SR.

J Infect Dis. 2017 Jun 1;215(11):1684-1694. doi: 10.1093/infdis/jix192.

Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study.

Hebbard AIT, Slavin MA, Reed C, Trubiano JA, Teh BW, Haeusler GM, Thursky KA, Worth LJ.

Support Care Cancer. 2017 Jun;25(6):1923-1930. doi: 10.1007/s00520-017-3606-y.

(May 2017)

Influenza vaccination responses: Evaluating impact of repeat vaccination among health care workers.

Leung VKY, Carolan LA, Worth LJ, Harper SA, Peck H, Tilmanis D, Laurie KL, Slavin MA, Sullivan SG.

Vaccine. 2017 May 2;35(19):2558-2568. doi: 10.1016/j.vaccine.2017.03.063.

Voriconazole for prophylaxis of invasive fungal infections after allogeneic hematopoietic stem cell transplantation.

Marks DI, Liu Q, Slavin M.

Expert Rev Anti Infect Ther. 2017 May;15(5):493-502. doi: 10.1080/14787210.2017.1305886.

(Apr 2017)

Changing epidemiology of candidaemia in Australia.

Chapman B, Slavin M, Marriott D, Halliday C, Kidd S, Arthur I, Bak N, Heath CH, Kennedy K, Morrissey CO, Sorrell TC, van Hal S, Keighley C, Goeman E, Underwood N, Hajkowicz K, Hofmeyr A, Leung M, Macesic N, Botes J, Blyth C, Cooley L, George CR, Kalukottege P, Kesson A, McMullan B, Baird R, Robson J, Korman TM, Pendle S, Weeks K, Liu E, Cheong E, Chen S; Australian and New Zealand Mycoses Interest Group.

J Antimicrob Chemother. 2017 Apr 1;72(4):1103-1108. doi: 10.1093/jac/dkw422.

Erratum in: J Antimicrob Chemother. 2017 Apr 1;72 (4):1270.

Changing epidemiology of candidaemia in Australia.

Chapman B, Slavin M, Marriott D, Halliday C, Kidd S, Arthur I, Bak N, Heath CH, Kennedy K, Morrissey CO, Sorrell TC, van Hal S, Keighley C, Goeman E, Underwood N, Hajkowicz K, Hofmeyr A, Leung M, Macesic N, Botes J, Blyth C, Cooley L, George CR, Kalukottege P, Kesson A, McMullan B, Baird R, Robson J, Korman TM, Pendle S, Weeks K, Liu E, Cheong E, Chen S; Australian and New Zealand Mycoses Interest Group.

J Antimicrob Chemother. 2017 Apr 1;72(4):1270. doi: 10.1093/jac/dkx047.

New developments and directions in the clinical application of the echinocandins.

Chang CC, Slavin MA, Chen SC.

Arch Toxicol. 2017 Apr;91(4):1613-1621. doi: 10.1007/s00204-016-1916-3.

(Feb 2017)

Epidemiology of bloodstream infections in patients with myeloma receiving current era therapy.

Teh BW, Harrison SJ, Slavin MA, Worth LJ.

Eur J Haematol. 2017 Feb;98(2):149-153. doi: 10.1111/ejh.12813.

Economic evaluation of azoles as primary prophylaxis for the prevention of invasive fungal infections in Spanish patients undergoing allogeneic haematopoietic stem cell transplant.

Solano C, Slavin M, Shaul AJ, Marks DI, Cordonnier C, Cornely OA, Pagliuca A, Cragin L, Jarque I, Garcia-Vidal C, Sorensen S, Vanness DJ, Charbonneau C, Barrueta JA, Peral C, De Salas-Cansado M, Bow EJ.

Mycoses. 2017 Feb;60(2):79-88. doi: 10.1111/myc.12552.

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